CYTOCHROME C OXIDASE: Structure and Spectroscopy H. Michel, J. Behr, A. Harrenga, and , and A. Kannt Annual Review of Biophysics and Biomolecular Structure Structure and Function of Cytochromes C F. R Salemme Annual Review of Biochemistry TRANSITION-STATE ANALOGUES IN PROTEIN CRYSTALLOGRAPHY: PROBES OF THE STRUCTURAL SOURCE OF ENZYME CATALYSIS Elias Lolis and … function; i.e. Several reviews have recently appeared that Cytochrome c oxidase is the last enzyme in the respiratory electron transport chain of mitochondria. James F. Collins, in Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals, 2017. Carter, K. Palmer, G. 1982. It contains three copper ions, which are necessary for its function. Cytochrome C oxidase (CCO) is composed of 13 protein subunits. Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits. Second, cytochrome c oxidase, an enzyme known to reduce oxygen to water at the end of the mitochondrial respiratory chain, has been shown to have a new enzymatic activity- … Cytochrome c oxidase (Cox), * which contains 13 subunits, is the terminal oxidase of cell respiration. Cytochrome C Oxidase. The three major subunits of Cox are encoded by mitochondrial DNA and form the functional core of the enzyme; this core is surrounded by 10 nuclear-coded small subunits. The enzyme cytochrome c oxidase or Complex IV, EC 22.214.171.124, is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes. J Bioenerg Biomembr, 38 (5-6): 283–291. Cooper CE(1), Nicholls P, Freedman JA. This structure has provided a basis for understanding the mechanism of the redox-coupled transmembrane proton pump which is the key component of the respiratory chain in most aerobic organism. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. high-potential cytochromes c generally function as isopoten-tial electron carriers between a membrane-bound cytochrome b (or c ]) and the most oxidizing protein electron acceptor of their respective electron-transport chains (Figure 1). Cytochrome c oxidase deficiency is a genetic condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver.Signs and symptoms of cytochrome c oxidase deficiency usually begin before age 2 but can appear later in mildly affected individuals.. Cytochrome c oxidase is an integral membrane protein that contains multiple redox active metal centers. The crystal structure of cytochrome c oxidase from the soil bacterium Paracoccus denitrificans has been reported. Additionally, it has a strong absorbency in the far-red to near … Author information: (1)Division of … Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It … Its main function is to convert molecular oxygen to water and … Abstract.